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Identifying a potential biomarker of Boxer arrhythmogenic right ventricular cardiomyopathy(ARVC)

Anti-desmosomal antibodies as a potential biomarker of Boxer arrhythmogenic right ventricular cardiomyopathy.

Status: Suspended

Species: Dog

Veterinary Speciality: Cardiology

Description

ARVC is common in the Boxer dog estimated to affect as many as 20-30% of  The purpose of the study is to determine if a specific blood test can be used to detect arrhythmogenic right ventricular cardiomyopathy (ARVC) in Boxer dogs. The test looks for a substance present in the blood of affected dogs, similar to that found in the blood of people with the disorder, arrhythmogenic cardiomyopathy. This blood test is currently investigational and experimental, and not a clinical test that will be reported. To determine how good the blood test is, we will measure the proportion of affected dogs that have a positive test, and the proportion of unaffected dogs that have a negative test.

Inclusion Criteria

  • Client-owned Boxer dogs of either sex or neuter status will be enrolled in this study
  • Participation is limited to those clients that can travel to Grafton, MA for all required visits.

Exclusion Criteria

Dogs that are pregnant or lactating, those with congenital heart disease (e.g., subaortic or pulmonic stenosis, or obvious septal defect), and those that have moderate to marked azotemia, known infection, an inflammatory leukogram, or evidence of other systemic disease that may impact biomarker levels will be excluded from the study.

Client Benefits

 The study will cover the costs for your dog’s exam, bloodwork, echocardiogram, ECG, and Holter monitor today. Your pet’s participation will also allow us to gain information which may help in the diagnosis and treatment of other Boxers with this condition. You understand that your animal’s participation in this study may not alleviate or cure his/her ailment.

Sample or Data Requirements

If you decide to participate in this study, your dog will have a physical examination, electrocardiogram (ECG), echocardiogram, and 24-hour Holter monitor. He/she will also have 15 ml (approximately one tablespoon) of blood drawn. After this testing is completed, your dog’s participation in the study will have ended.

 

Contact Info

For questions regarding the clinical trial please email the clinical trials technician, Diane Welsh at: clinicaltrials@tufts.edu

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