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Effects of a new drug combination on the reflux/vomiting in dogs undergoing anesthesia

The influence of premedication with acepromazine and dexmedetomidine on vomiting, gastroesophageal reflux and regurgitation before and during anesthesia in dogs

Status: Recruiting

Species: Dog

Veterinary Speciality: Anesthesia


Our overall goal is to measure the incidence of vomiting, gastroesophageal reflux (GER) and regurgitation in dogs after pre-anesthetic administration of acepromazine and dexmedetomdine . These complications can potentially result in severe esophageal damage and aspiration of stomach contents causing pneumonia .

This study will allow us to identify the most efficient drug regime that reduces the incidence of GER and regurgitation during anesthesia in particular in those patients more predisposed to gastrointestinal complications. The study will also allow us to institute early treatment with antiemetics and gastrointestinal protectants once GER is detected. It is also our aim to raise awareness in regards to these potential complications.

Inclusion Criteria

Healthy dogs that are scheduled to undergo an elective soft tissue or orthopedic procedure that are:

  • 6 months to 8 years of age
  • Male or female
  • weighing 5 kg (11 lb) to 35 kg (77 lb)

Exclusion Criteria

  • Dogs will be excluded from this study if they have vomited or regurgitated within a week of the scheduled elective soft tissue or orthopedic procedure.
  • Dogs will also be excluded if the randomized treatment does not provide enough sedation to place an intravenous catheter in a safe and ethical manner.

Client Benefits

Participation in the study will allow us to identify peri-operative regurgitation and reflux earlier than if your pet was not included in this study. If there is evidence of regurgitation during the procedure, your animal will be promptly treated (suction and/or esophageal wash). This study will also provide data of the occurrence of perioperative reflux which would not be otherwise identified. The information will be considered in the postoperative management of your pet. Your pet’s participation will also  allow us to gain information which will help in the management of other dogs in the future that undergo general anesthesia

Contact Info

For questions regarding the clinical trial please email the clinical trials technician, Diane Welsh at:

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