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Drug dosing in diabetic dogs

Development of an in vitro model for individualization of drug dosing in diabetic dogs.

Status: Recruiting

Species: Dog

Veterinary Speciality: Endocrinology/Metabolism, Internal Medicine


Poor control of the glucose levels in diabetic dogs can alter how the drugs behave in the body, which can result in drug toxicities. The changes in blood proteins caused by diabetes can significantly affect the disposition of the many protein-bound drugs used in diabetic patients. This study will explore a model that will allow identification of changes in protein binding that will improve the safety of giving different medications to diabetic patients. This study has the potential to help diabetic dogs to receive appropriate medical care and have a better quality of life.

Inclusion Criteria

Well diabetic adult dogs that weigh at least 3 kg (6.6 lbs) of any age and breed will be included in the study.

Exclusion Criteria

Sick dogs, those receiving drugs known to be highly protein bound, and hypoalbuminemic dogs will not be included in the study.

Client Benefits

The study entails having 2-3 teaspoons (12-15 ml) of blood drawn from your dog.  As an incentive, the study will cover the cost of a blood chemistry profile that would be performed as part of your dog’s visit.

Contact Info

For questions regarding the clinical trial please email the clinical trials technician, Diane Welsh at:

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